It very much can be if the bike needs to be hung. The hooks have limited capacity.

I have had to deflate my rear, 37c tire while hanging a bike on the Vermonter, which has roll-on service. Had to re-inflate the tire before riding to the hotel.

When I took the Pennsylvania (train-side checked) to Pittsburgh, I was sure the baggage handler was going to break a spoke as she struggled to get the bike down from the hook.