Originally Posted by Paul_P

I've just discovered (had to work it out though I'd heard it here before) that the relation between saddle position and the BB axis (arrived at indirectly through saddle to pedal spindle distance at an ideal leg extension/power application) is the most important adjustment as everything else is derived from it. Everything (rider, saddle and hand position on handlebars) then rotates around the BB axis. I believe that saddle tilt would be the last thing to adjust since it's what counters gravity to adjust the weight on the hands.