The basic rule of thumb - finger tighten the skewer with the QR pointing away from the bike - doesn't work as well with a Ti skewer. If you do that and then cam the skewer down, it's not as tight as a steel skewer, for all the material properties being discussed here.

So what I do is start with the rule of thumb, and then I flip the QR towards the wheel...but the opposite direction of camming down the skewer. That gives me leverage to rotate and tighten the QR another 180 degrees or so. And THEN I cam down the QR in the direction that tightens things. I know that I'm doing it right when pushing the last 30 degrees of QR tightening requires good hand strength.

I've bombed down hills at 45mph + with the wheels secured using this method. And I'm still here, so it works. But the only reason that I'm using them is because I was gifted them. And they match my bike quite nicely. I have not and would not buy Ti skewers otherwise. I've retired from weight weenie obsessions.