My contribution to the thread...old Schwinn voyager touring frame (that needs a new home, haha) with 700c to give perspective for comments above. 52 cm frame
The small 48cm Cannondale I have up locally is around 28.6 inches stand over.
So an early Cannondale touring bike at 48 inches might be a good gravel/road bike?
So looking at a stand over of 74 cm, then add say 3 for tires... So stand over with tires around 30” for a 52 cm frame.