As an example, consider the interesting stuff that they can do with insulin clamps etc these days. They can basically make a healthy person highly insulin resistant overnight. And they can reverse it just as fast. That being the case, why does clinical IR take decades to develop an nearly as long to truly revers (if, in fact, it can be reversed)? There simply has to be more to the story. Mitochondrial atrophy, altered gene expression, fat accumulation in weird places... something.