I have a Domane AL 3, not sure which generation. I've been to the Blue Ridge Mountains on a motorcycle, maxi scooter and in my old Miata. Those hills would be challenging on a Domane.

I find the low gear (1:1) is not quite low enough for that sort of climbing in my particular echelon of cycling. You may want to have your local shop look into chainrings with a wider range, or at least lower. I don't remember who said it originally, but it is so true: "What you don't have in your legs, you'd better have in your gears."

Beautiful place to ride, but the nicest roads most often don't have shoulders due to lack of real estate. Make sure you outfit yourself with good daytime-visible lights. We don't want to read about your getting nudged off a mountain by some reckless cager.