I take just Losartan. I had a mild scare a few weeks ago after taking one Celebrex…made my heart rate rise and my BP went way up. It took over 48 hours to get that stuff out of my system. Caffeine made it worse. So, now I limit my caffeine intake, which by the way is a diuretic and can possibly make one’s BP go up. I do not have tea after 3:00 in the afternoon…and I’m sleeping better! Now, my BP is much better and I’m doing better things for my body so that I don’t need the Celebrex.