Your post is somewhat confusing.
Are the spokes getting loose? Use a spoke prep or green locktite. Proper spoke tension "should" keep them from loosening.
OR
Are the hub bearings getting loose?

How much do you weigh and do you mash low gears?
EDIT- Identifying the rim, spokes & hub as much as possible can be useful.
Spoke count & "speeds" can also be a factor.