Reach and Stack, help in determining some general start point for a rider position and posture on any type of bike (mtb, road, TT, gravel, etc) relative to what they're looking for and their body structure.
Reach and Stack, for a rider who already has/had multiple bikes will likely be compared and adjusted relative to how they ride their other/prior bikes...
There are no absolutes, even are no real 'median zones' for Reach and Stack - it's what you wish...
In your bike list you have a number of performance road bikes, including an AL Domane.
So I would advise considering what differences you wish in your position and posture and relate that to the existing/prior bikes and then consider what you want from the new Domane.
Higher bar height? Less Reach to the bars? The frame is only the foundation to that - so many other things affect that, like Stem and Bar...
Or are you just wanting a New Bike ? Or the new 'stuff' on the bike? How much is about the bike and how much about the riding?
Often 'comfort' things are grounded, not in the bike, but in your posture - which unless you address that directly, a new bike may not make a difference.
Ride On
Yuri