Assuming the problem is hand numbness, no amount of padding is going to solve that. Maybe make it a bit better. The contact area of the hands is pretty small and not evolved to carry weight like that for long periods. Also, sometime numbness results further up in the hand where nerves are getting pinched and it's not right at the contact point.

As mentioned bike fit is key. But something I struggle with is my weight. When I'm less fat, I have much less hand numbness. At the moment, I'm 40 lbs heavier than a year ago and I get a lot more hand numbness now.

Something I found really affects the load on my hands is saddle tilt. I need the nose just a tad high to support my pelvis a bit better.

Another thing is power output. The harder you pedal, the more of your weight is being put into your legs. This lightens the load on your arms/hands and your saddle.