I do have a box of nitrile gloves on my work bench and wear them when I know I'll be doing something particularly messy (e.g., overhauling a bottom bracket). Years back, we had this product in the bike shop:

https://pr88gamp.com/

You slather a marble-sized ball on your hands, and then grease and grime magically wash off with water once you're done wrenching.

I also use a set of heavy-duty gloves like these:

https://www.homedepot.com/p/G-F-Prod...5L-6/202710241

That's after severely gouging my thumb on a chain ring while trying to remove a rusted bit. They also work really well when I want more leverage to undo something stubbornly affixed.