Hope you're doing well.

If the two holes are pinholes (like that caused by a a thorn or wire) and can both be covered by the "thick" part of the patch, you can use a single patch to seal both. Multiple holes that aren't pinholes (such as the dreaded "snakebite" slits from catching a tube under a tire lever) can be trickier, as if not sufficiently spanned the slits can tear beyond the patch under pressure.

You can overlap patches - thinner patches such as Rema make that easier. But you need to prep the top of the first patch where the second patch will cover it, similar to prepping the tube by removing all old oxidized rubber, dust, and contaminants. A successful example: