That is indeed one of the principal appeals of the smaller 16" wheel family (305, 349, 355): easier acceleration and deceleration, and the spirited, lively feeling that comes with that. Add a short wheelbase and now you've got super agile, responsive handling and the ability to turn on a dime, coupled with spirited, jack-rabbit acceleration. This all makes for a very engaging, euphoric ride like no other, particularly apt for urban operations. Small wheel + short wheelbase = FUN
16" (349) wheels, 92cm wheelbase.
As for riding long-distance, long days in the saddle on these small wheelers, why not? I've done several 100km+ days in them. So long as you've got the physical condition and stamina, and the bike fits comfortably, it's fine. Here I am on long-distance, cross-country tour in South Korea on a 16" (305) small wheeler.