I and my friends have a couple of Trail Blaze builds.
It has a standard BSA 68mm BB and a 142 thru axle rear O.L.D., so when using wide tire (>2.0), the chain may interfere with it. One of solutions is to consider a wider crank.
And regarding the cassette, I don't think 50t will fit, because you can only use short or middle cage RD.