The Nexus 8 will use a 36 hole hub. You can use mild double-butted spokes to save weight. 700C size is available pre-built and ready-to-go.

It has such a variety of gear options that you should have no trouble with vertical drop-outs--just add or subtract a gear tooth.

KMC also makes a 3/32 compatible half link for vertical drops. You can find the half link plus a new chain (like a z71 or a SRAM 57, 67), plus the required NEXUS vertical drop washers at any QBP vender such as Harris Cyclery or Airbomb

Harris has on-line gear calculators and some charts that show gear equivilency of the Nexus 8. Figure out your minimum and maximum gearing requirements and adjust accordingly (perhaps need to change a front chainring or purchase an additional $4 Nexus gear). This is all made very easy. Compare the internal gear calculator with the exact same settings on the derailer calculator and you've got it.
*Ignore fictional speed results like 25 mph unless you've rid yourself of the slow hybrid tires and use something like Panaracer T-Serv (weather) or Pasela Tourguard (dry) in a size like 700Cx28mm. These two, I recommend because they're fast, cushy and have traction. You can get the Pasela TG bigger, but keep the T-serv small because it is sticky.
*Work out your desired low gear first and just let the top end fall where it may. 300% is enough range to do both jobs.


Nexus 8 premium version has double-bearings for longer life and extra speed.
Available pre-built to 700c at Harris Cyclery. QBP catalog also lists a pre-built if you prefer a different rim.

All internal gear hubs go slow for the first 300 miles (maybe not that much) until the very tight bearings get some wear, and then you're good to go.

SRAM S7 is an identical option, but is far lower geared, --useful if you live in the mountains or San Francisco. While the insides are slightly more durable in hilly areas, the $40 outboard shifter is an annoyance when you crunch it.

Use an SRAM or Campy chain if you intend to put more than 1000 miles per chain.