All depends on how anal you are. If you're like me, you'll pull the chain, cassette, chainrings and soak them in mineral spirits every ~500 - ~1000 miles depending on conditions. Chain gets done more often though. I clean up the frame with Honda motorcycle polish every 3-4 rides. I always clean the sweat off after the ride, very damaging stuff it is.
I also know a guy who puts around 300 miles a week on his titanium bike and hasn't cleaned it once. Just regular chain swap out. His bike looks like hell though.