I used Chamois Butt'r for the first time in earnest this weekend as I went for my first long ride of 79 miles. I'm pretty sure it helped but only after I got in the shower did I realize that I probably could have been a little more generous as the warm water highlighted some slight chaffing between my legs. Nothing major...all was good the next day. Per someone's suggestion I also used it between my toes and didn't have any issues with blisters.