Assuming that your feet do not hit your panniers, you are good to go except perhaps for the width of your tires. If your frame will accommodate them, I would suggest 32mm tires and that you stay on pavement. I would recommend Continental Top Touring or Specialized Armadillos.

If you are a lightweight (<140 lbs) you might be OK with 25mm, but you should inflate to the max and be aware that the ride will be a little hard. Bring along a spare, as your rear tire will wear quickly wear out.