specialized dealers have a piece of foam you can sit on to measure your sit bones. Specialized also sells a few saddles with a variety of width options. (not that i have tried them or am endorsing them, it was something i found about after getting my Flite via ebay.)
For me having a little bit of padding and a saddle that is the proper width seems to be key. I have a non jell Selle Italia Flite and a stock saddle from a 80's nishiki. the nishiki saddle is more conformable i think because it is a bit wider. im sure it helps that the nishiki is not nearly as stiff as my track set up with the flite saddle ( deep v's & a bare knuckle frame)
edit: the flat vs round seat might also have something to do with it. the nishiki saddle is round vs the flatter flite.