Yeah, one of my friends at university got busted for DUI on his bike. Really kinda sucked because this was a college-town with tonnes of inebriated kids everywhere! I guess running a stop-sign attracted more attention from the cops than he bargained for... Really unfortunate because I ran 100 stop-signs in one night once...
And there's also a couple of clubs where the cops have a stake-out and checkpoint. You don't even have to drive drunk, you just have to put the key in the ignition and they can bust you for DUI...