SS road/cross? Chain length would be the only challenge with vertical drops, but with the right gearing and maybe a half link I imagine you could get it close without going to an ENO eccentric hub. For geared, pretty easy breezy. I have an old Bianchi Grizzly that I use for touring. The only consideration (apart from it being a little on the heavy side) is the use of road levers with cantilever brakes. I needed to use an extra wide hanger for my old bike, otherwise the lever travels through it's range without grabbing hold. I also use 26". I'm not sure if 700's would fit. I should try that, though. Hrrmmmmm....

ps congrats to sr20det