When I got back into cycling in a big way, I had some comfort issues with the road bike saddle. I wrapped it up with cloth strips from old t-shirts and duct tape and thus became a laughing stock. So abashed, I removed it, had some pain for a bit, got used to it, and it became a non issue.

When I got a beater that came with a big ass, wide cushioned saddle I thought to give it a try. After ten miles, I found it excruciating for the chaffing and swapped it with a cheapo road saddle. Way better.

Give it time.