I run Tufo w/sealant.

I had my first puncture this morning. I stopped when I heard the air coming out, rotating the tire so that the puncture was at about the one o'clock position. I watched the sealant do it's thing. After it sealed, I gave the tire a squeeze--plenty of air left in it! I continued my commute with no further regard for what just occurred.

I'll give the tire a better inspection once I return home. If there's a cut, I have a method using congealed rubber cement and tire patch glue to close up the hole with more rubber.