My commute into the financial district is always pretty hectic. I ride along Adelaide from Bathurst to Bay St, and then down to Front. On the way home I take Richmond instead of Adelaide. I think I need to find a new route... despite there being 4 lanes most of the way cars still feel the need to buzz me, honk at me and tailgate me. The road is also super crappy and criss crossed with degraded streetcar tracks. They should dedicate a lane on one of those streets for bikes... there is so much room for it. I can see the fear in alot of the bike commuters eyes going along there during rush hour, and I've had a few close calls already. The safest parts of my commute are when I run red lights on some of the smaller streets crossing Adelaide because I get a nice stretch of road without any traffic going by me.
I find a good tip is to always do alot of shoulder checks when you know a car is coming up behind you. This makes the driver acknowledge that you exist and they will tend to give you a little more room and will pay more attention to your upcoming actions. Also signaling helps alot at getting cars to give way to you.