I've done it, front and rear. Front held up just fine. Broke four spokes on the rear. I can't tell you if that's because of the lacing pattern, or if that's because I'm a ****ty wheelbuilder. The pattern is basically 3x arranged slightly differently, so I've heard that in theory it should be just as strong. My newer set of wheels is 3x in the rear and holding up beautifully, if that makes any difference to you.