Joined: Jul 2002
Posts: 40,863
Likes: 3,115
From: Sacramento, California, USA
Bikes: Specialized Tarmac, Canyon Exceed, Specialized Transition, Ellsworth Roots, Ridley Excalibur
Merlin has the best answer, but if you want others' experiences, here's mine:
Campy Record 53-39 crankset, Centaur 10spd RD, 12-25 cassette: Can use all 10 cogs on the big ring, but I get some rub on the 39-12 combination.