Nothing is "industructible". You can only toughen up a bit more of the best product you can afford to make it less prone to pinch/damage and carry some spare patches (or tire) and hope for the best.

I am using Continental Travel Contacts right now. I would peg around 800 km milage on them since I changed my knobs to semi-slicks for smoother riding. I ride on the road and my area has piss poor roads with bad potholes, jagged potholes, glass, and sharp pointed pebbles. I avoid the potholes as much as I can but often I am forced to attack the glass head-on as ******* cagers always crash up around the place and thus why my part of the city has (according to the TV news report) the highest insurance rate of all of Toronto. Anyways a quick status on my tires. My front tube is original and never repaired/pinched and now has around 1900 km's on it. The rear tube is original but has been patched once (as the bike was in storage for 10yrs so yah pinchy goodness) but still holding out strong at around 1900 kms as well. I changed my knobs around 1200kms I think and since I've got those Conti's with kevlar I've been riding daily head on over said hazards. I avoid as much as I can but apparently the tires hold up and I don't notice and cuts into the tires.

As someone else said a tire liner is a good idea for extra peace of mine and durability. Might do that myself later when I can afford it. If you're taking your bike 4 seasons and you're in a region that gets snow/low temps you might not want to go cheap and spare no expense to line, beef up, and get the best tire/tube you can because tire repair/tube repair in the dead of winter (worst at night, colder) is the royal suck on the hands. If you're in a warmer region then well you can go a little cheaper as your hands won't be frozen up and you can do some repairs (knockon wood that you don't have to *knock knock*) if/when needed.

*edit*
I use a MTB with 26" x 1.75" Conti's.

Zero_Enigma