Try changing your cleats on your shoes by moving them forward or backward 2mm. You should notice the difference, esp on a long ride.
Once your bike is dialed in, any adjustent of 2mm or more you will probably notice.
When my left ITB went south I lowered my saddle 3mm and was able to run that way throughout the season.
I thought I could leave the saddle at that height until I started to experience some pain on the inside of my knee to which I discovered the cure is raising the saddle. Put it back to the pre-injury height and two rides later all pain went away.
On another note, it is recommended that changes in crank, cleats and shoes that cause a difference up to 2mm is prefered to using shims.
Think of balance and comfort. A difference of 2.5mm is really a differnece of 5mm from pedal to pedal which could make a differnce (1/4 of an inch) esp over a long time.
Most of my setup issues don't affect me until around 80 miles.