Originally Posted by GuitarWizard
Once you get beyond 10,000 feet, you can gain around 2,000 feet per day without issues. Below that, acclimatizing happens much more quickly, and having 3-4 days to adjust is certainly better than 0 days.
And it's worth noting that a good chunk of the route is under 8,000' (base elevation of Bishop is ~4,000'). Only the first climb of Day 1 and the last climb of Day 2 go over 10,000' (and just barely over at that).
It would seem that one's training and other preparation will greatly outshadow any benefit derived from acclimatization, though of course if you can get there 2-3 weeks ahead it probably wouldn't hurt anything.