I rode a nondescript Specialized saddle on my MTB converted to road bike for a couple of years. Then put that on my new Surly LHT, thinking that since it was comfortable on one bike, why not the next...not true. It felt mushy and when I asked at the LBS, the fitter said I was too big & heavy for that particular saddle (6'5", 220 lbs) and the mushy feel probably indicated that it was beginning to show the stress. So I went with a Specialized Body Geometry saddle. The comparison between the 1st & this saddle is remarkable. I suppose I had 'worn' the 1st generic Specialized saddle out...? and not just that the LBS wanted to sell me a different saddle.

If you weigh 160 - 180 pounds, probably any saddle will last a long time. If you are heavy enough (over 190-200 lbs) I think some saddles will not endure. My next venture will be a Brooks B-17 but that's for my summer birthday occasion. There doesn't seem to be any indication of a weight factor affecting Brooks saddles, at least not that I've read anywhere on these forums.