Commercial jets are pressurized so that the cabin and baggage area pressure is equivalent to 10,000' altitude when the jet is cruising above 30,000' At that pressure altitude, the ambient pressure if about half of what it would be at sea level, so the pressure differential between your tire and the ambient air is only increased by 7 or 8 psi. (That's a rough guestimate, it's been a while since ground school)

This pressure altitude is equivalent to taking your bike to the top of Haleakala on Maui. How many riders would deflate their tires for that ride?