I'm in the initial stages of riding a Selle Anatomica saddle. So far, the first thing I noticed is that my butt and sit bones feel great on this saddle. I've tried the Selle SMP, Specialized Alias & Milano and this one is more comfortable on the bones. The perineal area felt good but I only rode about 1.5 hours. I'll delay comment on that until I've had a chance to get out for a 3+ hour ride. There are some questions that can't be answered now as the saddle is new and time will tell how it holds up. But there's no pinching in the sensitive areas. There is a potential for chafing of the inner thighs along the saddle horn ( I experienced this on my very first ride). I tweaked the setup, slight tilt down and slight shift rearward and it seems to have eliminated the problem. I'm really hoping this one works out. But my 2nd best saddle is the Specialized Alias. Although the seat area is harder then the Anatomica, the split down the middle alleviates any perineal pain.