Cycling is my fastest option. I don't own a car, so that's not an option for me. The streetcar in the morning particularly stops at 99% of the stops along the route, if I take that direct route I can make the ~3-4 miles in 12-15 minutes. I usually prefer to ride across the lakefront for more scenery and no traffic, that's around 17-20 minutes and usually always faster than the streetcar.
My previous commute from the east end would take almost the same amount of time as public transport (mixture of two subways and a streetcar), my bike route was more direct but overall slower average speed, which made the two almost the same. Unless it was a VERY rare slick-fluid day of quick transfers, the bike always had the edge (consistent 30-35 mins versus anything from 30-50 minutes by TTC)