Guys,
If the OP is talking about drilling holes himself, I'm guessing it ain't Masi he's tapping.
In any case, I don't think the OP had brazing fittings on and repainting in mind.
I hat to see anyone drill any old frame, if they aren't a builder. I wouldn't drill a Schwinn Colliegiate, for xxxxxsakes.
There are many alternatives for fenders/bottles besides drilling holes, which is what the OP asked about in the first place!
Sorry for ranting, long day.