I never miss this ride. I'll probably be doing the double-metric version (at least I hope to), and I am slow, so I will be starting early.
Note to anyone considering the 100 / 125 mile options: the 100 mile route contains a 20 mile very hilly stretch on the same road. Not only do you not turn, there is no place to turn even if you wanted to! It's physically and mentally taxing, which is why most people think the 125 route is actually easier then the 100 route is.
Note 2 for 100 / 125 mile option riders: there are only two "official" rest stops, one at mile 24, and the other at mile 80 / 100. There are country stores on route, so be prepared to "make your own stops".