There's many types of Nisi's. If they are Sludi 290's they are a nice lightweight rim. But they do not have eyelets and need to be built with washers under the nipples. If they are not tensioned correctly you can dimple the rims around the spoke holes.

Fiamme Red Labels would be a better choice for all around riding, as they are pretty bullet proof. But nothing against Nisi's if built right.