Why the Haines-Kluane-Skagway loop?
Because it's about a week -
Because the scenery is spectacular -
Because it isn't brutally remote -
Because you get to sail thru the Lynn Canal -
Because Whitehorse is a fun city.

The bugs aren't that bad - you just need to be prepared.
There are mosquitos in Banff and Jasper, too.

As I said earlier, by riding north on Vancouver Island,
you get the chance to acclimate to less and less population.
The ferry rides are wonderful - and all the little port towns.
Alaska/Yukon would be more of an adventure.