uh- numbnuts?

Seriously though, not sure if there is any advantage other than finding the correct angle that makes it most comfortable for you to ride. I think you may find that very small changes will have significant affect on how it feels. I find my saddle tilted nose up does truly make me numb. Tilted nose down I always feel like I am sliding forward and spending energy trying to maintain my location on the saddle. And I am talking a degree or two of change. No two people really have the same anatomy, so YMMV.