I used to ride an Aluminum Marin Argenta. It was a nice ride for an average day, but I do all Ultra events. My first 24 hour race on it was a nightmare. After the first 150 miles, the road buzz made my arms almost numb up to my elbows. By 200 miles I could barely feel my hands on the bars, it just felt like they were asleep. I finally called it quits at 280 miles because it was so bad. I soon switched to a CF framed Giant and a CF Planet X TT, and have never had that feeling again.

I am sure with a better Aluminum bike it wouldn't have been as bad, but the Marin was low/mid range and not my favorite ride. I definitely don't want my mileage to be limited by my bike, that is what my excess weight and lack of talent are for...