I have a neuroma in my right foot and had custom orthodics made 9 years ago to help.

The orthodic has an extra thick pad (bump) that pushes the third and fourth joints apart to prevent the pinching that causes the nerve to hurt.

I haven't worn my orthodics for a while because I'm too lazy to get back to a podiatrist, but as long as I have on shoes that are wide across the forefoot, then I'm okay. Narrow shoes absolutely kill my right foot with pain from the neuroma.

I wear a pair of Sidi Genius Megas (the wide version) for riding and can ride all day with little to no discomfort from the nerve.