From a previous thread...

A Morton's neuroma describes a nerve inflammation in the 3rd interspace. A Joplin's neuroma describes a nerve inflammation in the 1st interspace. Morton is just the guy who described the nerve inflammation within that interspace.

The nerve inflammation is generally due to compression of the nerve between the metatarsal heads. There is not a whole lot of conservative treatment for them but conservative therapy generally works well.

Most important is to support the transverse metatarsal arch (the arch from the great to the the 5th toe) and prevent pronation, which causes the metatarsal heads to 'cross' and pinch the nerve. Use a metatarsal pad with an orthotic. This control needs to happen all the time, not just when cycling. So control the motion walking and what inflammation you have may not cause pain when cycling. Also, shoes that are the right width are crucial. Any compression of the metatarsal heads will cause compression on the nerve.

Then the usual inflammatory treatments. Ice, NSAID's, cortisone injection, etc...

Surgery is always a last resort. One can try to sclerosis the nerve with dehydrated alcohol prior to surgery. Surgery to decompress the interspace by releasing the intermetatarsal ligament and remove the common digital nerve is not uncommon but as with any surgery it comes with its own possible complications....