i destroyed an axle that way, when i was courierering. when ever i try and accelerate hard or go up small inclinations the torque would force the wheel to shift causing the chain to slip UP the cassette and putting so much force on the chain it couldnt move anymore.

my problem may have been the ****ty quick release. stopping and fixing the chain several times a day eventually the axle bent then cracked and so did the qr skewer. quite a ****ty way to start your day at work.