I'm running 36 hole Open Pro's on my geared bike; 36 hole Velocity Deep V's on the fixed gear. Same tires on both (28's). I don't remember what spokes were used. Both sets were machine built and then hand tensioned and trued by someone who knows what they're doing (in other words, not me). Both have held up well but if I had to pick one I'd go with the V's. The Open Pro's have loosened up a bit, nothing that requires truing but just enough that I can notice it. The V's are as tight as the day I got them even with the stress of fixed gear stoplight racing and downtown potholes.
Can't really speak to drilling out for Schraeder as the last time I did that was 15 years ago on a Mavic 231.
For reference I'm 6', 260 lbs.