Do the route at least once on a day off to see how long it will take and if there are any surprises. Watch out for areas that might have broken glass, construction debris, etc. Decide how you want to go over the bridge (does it have a bike lane? If not, I, personally, recommend the sidewalk since cars topping the bridge won't be able to see you and they can come across at quite a clip).

Decide how you're going to handle the change of clothes. Are you going to stage clothing at work? Carry it with you? Do you have a shower?

Other than that, just use common sense and stay paranoid, at least until you're really comfortable with the route and the drivers are used to seeing you.