I had Look Keos. I sold them and got Speedplay Zeros (first ride today).
I was tired of trying to get my keo cleats adjusted right. The speedplays offer a lot of adjustment options and its a lot easier to adjust. Yes fore/aft adjustment requires you to take off the cleat, but I got it set right so no need to mess with it anymore. Its left/right setting that i'm getting hungup on.