Yep thats what I do. I have docking stations at home and work, so I only have to carry the laptop and none of the other stuff (power supplies, mouse, etc.) I got the smallest padded sleeve I could find that fit my laptop and a few other things (note book, pens, access card, token, etc.) I can fit it, a change of clothes and misc other stuff in one pannier (Rack Pack 1).

I wish I didn't have to carry it, but the security restrictions at work do not allow loading the VPN SW or company data on home personal computers, and they only provide one. I split time working from 2 locations, so I have to have it with me.