Planning on camping or staying in hotels? Day time temps would probably be fine, but it can get pretty cold at night. Average temps in Florence, SC: upper 50s and mid-30s for that time of the year. Tonight it's going to be in the 20s. Anyway, I've only driven on I-20 and I-77 through that part of SC, I'd be interested in hearing about touring there; I might do it when the weather warms up enough for me to camp.