No, but it won't fill your tire either, unless you know exactly what to do. The pressure goes down, not up in the cold. As the cartridge emptys at room temperature they get covered with ice from the gas expansion. That's how air conditioners work.
This means that the nozzle will ice up and the co2 will not fill the tire much any way. Even at plus 25 degrees F it's a problem.
If you put the whole cartride under your coat until it is warm, and act very quickly you can fill a tire (sorta). If you are too slow it ices up. Covering it with a gloved hand helps.

Below freezing, bring a pump.

Don't leave them in the car during the summer, they can explode and blow out the windows.