I use a 17/19 Dos ENO with double chainrings (44/42) on my commuter bike with fenders. No chainline issues, the rear brake pads always line up (because the number of teeth total is the same for both combinations), and I have a "headwind gear" on those afternoons when I need it. It works well and I'm very satisfied. The ONLY reason I bought the Dos ENO was because flipping the wheel on a fendered bike is a PITA.