I'm with the 'change the wheels first' school of thought. You'd be surprised at how much your frame and wheels flex.
I love my 10 speed 105 stuff. It shifts really well and I have absolutely no complaints. I'm going to run this group down to the ground before I even think of upgrading. The brifters act funny sometimes when I go to shift and they don't engage, but I think that's because of the angle my brakes are at. I try again in a second and it works.
I'm referring to the front brifter, where I can't shift to my small ring because the black paddle just goes all the way over to its rightmost position without shifting almost like it didn't engage, and then when I try again it goes over like nothing was ever wrong. I'm accounting it to user error due to brake lever position. Any input?